The Rb-E2F pathway is involved in many biological processes, and its complexity is not yet fully understood. Understanding the pathway will require the integration of heterogeneous sources of biological data. Using a rule-based system, we can infer new biological hypotheses about the functions and relationships of the pathway.

The DICBP pathway database, pathway explorer and visualization system provide the evolving representation of multiple forms of genomic data, model/analysis summaries, and other information relevant to the integrated understanding of the Rb-E2F pathway arising from the program. At present, the database only contains human gene interaction data for protein-DNA interactions and protein-protein interactions. The data sources include:

• Microarray induction data from various publications.
• Transcription factor regulation data from UCSC Human Genome, TRANSFAC, JASPAR, DBTSS and BIND.
• Protein interaction data from DIP, BIND, HPRD, MINT, MIPS and the Human Interactome project in Marc Vidal's lab.

Pathways are generated by applying various database rules, and they are visualized with Cytoscape.

Using Java Web Start, you may access the DICBP database by clicking here: Launch Interaction Viewer. This starts Interaction Viewer on your own computer after downloading the program. On subsequent runs, the program will not be downloaded again unless we have newer versions for you to use. If Interaction Viewer fails to launch when you click on the link, you may need to install Java Web Start. A simple user manual for Interaction Viewer can be found here.